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A complete of 3 % of Energetic substance is excreted in urine as unchanged Energetic substance. Tapentadol is additionally metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 also to hydroxy tapentadol (two %) by CYP2D6, that are even more metabolised by conjugation. Hence, active material metabolism mediated by cytochrome P450 metho

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